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Article

Expression of Genes Associated with Telomere Homeostasis in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Samassekou Oumar, Bastien Nathalie, Yan Ju, Mai Sabine, Drouin Régen

Abstract excerpt

We describe a method that assesses the impact of specific mutations of TP53 and genomic instability on gene expression of the most important genes involved in telomere length and structure homeostasis. The approaches consist of using a reverse transcriptase method and a quantitative PCR that were applied to isogenic cell lines from a colon cancer.

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PMID: 29564829
DOI: 10.1007/978-1-4939-7780-2_16

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