Article
Study of Telomere Dysfunction in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018
Samassekou Oumar, Bastien Nathalie, Yan Ju, Mai Sabine, Drouin Régen
Abstract excerpt
Telomere restriction fragment, 3D quantitative FISH on nuclei, and quantitative FISH on metaphases are complementary approaches that explore telomere dysfunction genomically, cellularly, and chromosomally, respectively. We used these approaches to study association between telomere dysfunction and degree of genomic instability related to TP53 mutations in LoVo isogenic cell lines. We found a strong correlation...
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