Article
Molecular Modeling and Structural Stability of Wild-Type and Mutant CYP51 from Leishmania major: In Vitro and In Silico Analysis of a Laboratory Strain.
Molecules (Basel, Switzerland) - 19 Mar 2018
Keighobadi Masoud, Emami Saeed, Lagzian Milad, Fakhar Mahdi, Rafiei Alireza, Valadan Reza
Abstract excerpt
Cutaneous leishmaniasis is a neglected tropical disease and a major public health in the most countries. Leishmania major is the most common cause of cutaneous leishmaniasis. In the Leishmania parasites, sterol 14α-demethylase (CYP51), which is involved in the biosynthesis of sterols, has been identified as an attractive target for development of new therapeutic agents. In this study, the sequence and structure...
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