Article
Insulin resistance in cavefish as an adaptation to a nutrient-limited environment.
Nature - 29 Mar 2018
Riddle Misty R, Aspiras Ariel C, Gaudenz Karin, Peuß Robert, Sung Jenny Y, Martineau Brian, Peavey Megan, Box Andrew C, Tabin Julius A, McGaugh Suzanne, Borowsky Richard, Tabin Clifford J, Rohner Nicolas
Abstract excerpt
Periodic food shortages are a major challenge faced by organisms in natural habitats. Cave-dwelling animals must withstand long periods of nutrient deprivation, as-in the absence of photosynthesis-caves depend on external energy sources such as seasonal floods. Here we show that cave-adapted populations of the Mexican tetra, Astyanax mexicanus, have dysregulated blood glucose homeostasis and are insulin-resistant...
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