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Article

Kinetics of Secoisolariciresinol Glucosyltransferase LuUGT74S1 and Its Mutants.

Journal of agricultural and food chemistry - 11 Sept 2024

Moree Sadiq Saleh, Böhm Lukas, Hoffmann Thomas, Schwab Wilfried G

Abstract excerpt

The lignan secoisolariciresinol (SECO) diglucoside (SDG) is a phytoestrogen with diverse effects. LuUGT74S1 glucosylates SECO to SDG, whereby only small amounts of the monoglucoside SMG are formed intermediately, which exhibit increased activity. To identify critical amino acids that are important for enzymatic activity and the SMG/SDG ratio, 3D structural modeling and docking, as well as site-directed mutation...

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PMID: 39213532
DOI: 10.1021/acs.jafc.4c06229
PMCID: PMC11403609

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