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Article

Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans.

Emerging infectious diseases - 1 Apr 2018

Yamayoshi Seiya, Kiso Maki, Yasuhara Atsuhiro, Ito Mutsumi, Shu Yuelong, Kawaoka Yoshihiro

Abstract excerpt

To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2-482R, polymerase basic 2-588V, and polymerase acidic-497R individually or additively enhanced virus polymerase activity, indicating that multiple replication-enhancing mutations in 1 isolate may contribute to virulence.

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Share to Amino Acid Substitution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29553313
DOI: 10.3201/eid2404.171509
PMCID: PMC5875272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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