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Article

Superoxide dismutase 2 (SOD2) contributes to genetic stability of native and T315I-mutated BCR-ABL expressing leukemic cells.

Biochemical and biophysical research communications - 15 Apr 2018

Girerd Sandrine, Tosca Lucie, Herault Olivier, Vignon Christine, Biard Denis, Aggoune Djamel, Dkhissi Fatima, Bonnet Marie Laure, Sorel Nathalie, Desterke Christophe, Bennaceur-Griscelli Annelise, Tachdjian Gerard, Guilhot François, Guilhot Joelle, Chomel Jean-Claude, Turhan Ali G

Abstract excerpt

Manganese Superoxide dismutase 2 (SOD2) plays a crucial role in antioxidant defense but there are no data suggesting its role in genetic instability in CML. We evaluated the effects of SOD2 silencing in human UT7 cell line expressing either non-mutated or T315I-mutated BCR-ABL. Array-CGH experiments detected in BCR-ABL-expressing cells silenced for SOD2 a major genetic instability within several chromosomal loci,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Source

Identifiers

PMID: 29550484
DOI: 10.1016/j.bbrc.2018.03.023

Genes

SOD2
BCR
PRDX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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