Article

Whole Exome Sequencing Identifies Novel Germline Variants of SLC15A4 Gene as Potentially Cancer Predisposing in Familial Colorectal Cancer

2021-03-09

Abstract excerpt

About 15% of colorectal cancer (CRC) patients have first-degree relatives affected by the same malignancy. However, for most families the cause of familial aggregation of CRC is unknown. In order to identify novel high-to-moderate penetrant germline variants underlying CRC susceptibility, we performed whole exome sequencing (WES) on four CRC cases and two unaffected family members of a Polish family without any mu...

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Literature Corpus work: 19b44c26-998b-5adc-852a-dcba5acd0496
DOI: 10.20944/preprints202103.0257.v1

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