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Telomere dysfunction in hypertension

1 Nov 2007

Abstract excerpt

Aging is a major risk factor for hypertension and associated cardiovascular disease. In most proliferative tissues, aging is characterized by shortening of the DNA component of telomeres, the specialized genetic segments that cap the end of eukaryotic chromosomes and protect them from end-to-end fusions. By inducing genomic instability, replicative senescence and apoptosis, telomere shortening is thought to...

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PMID: 17921808
DOI: 10.1097/hjh.0b013e3282ef6196

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