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The molecular characterisation of mitochondrial DNA deficient oocytes using a pig model

19 Feb 2018

Abstract excerpt

STUDY QUESTION: What are the molecular differences between mitochondrial DNA (mtDNA)-deficient and mtDNA-normal oocytes and how does mitochondrial supplementation alter these? SUMMARY ANSWER: Changes to DNA methylation in a 5' cytosine-phosphate-guanine 3' (CpG) island in the mtDNA-specific replication factor (DNA polymerase gamma (POLG)) of mtDNA-deficient oocytes mediates an increase in mtDNA copy number by the...

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PMID: 29546367
DOI: 10.1093/humrep/dey052

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