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Article

Low oocyte mitochondrial DNA content in ovarian insufficiency

18 Dec 2004

Abstract excerpt

BACKGROUND: Mitochondrial biogenesis and bioenergetics play an important role in oocyte maturation and embryo development. We have investigated the relationship between defective mitochondrial biogenesis and the lack of oocyte maturity observed during IVF procedures with patients suffering from ovarian dystrophy and ovarian insufficiency. METHODS: We used real-time quantitative PCR to quantify mitochondrial DNA...

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PMID: 15608038
DOI: 10.1093/humrep/deh667

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