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Target-based drug design strategies to overcome resistance to antiviral agents: opportunities and challenges.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Mar 2024

Du Shaoqing, Hu Xueping, Menéndez-Arias Luis, Zhan Peng, Liu Xinyong

Abstract excerpt

Viral infections have a major impact in human health. Ongoing viral transmission and escalating selective pressure have the potential to favor the emergence of vaccine- and antiviral drug-resistant viruses. Target-based approaches for the design of antiviral drugs can play a pivotal role in combating drug-resistant challenges. Drug design computational tools facilitate the discovery of novel drugs. This review...

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PMID: 38301487
DOI: 10.1016/j.drup.2024.101053

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