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Article

Induction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal Homeostasis.

The American journal of pathology - 1 Jun 2018

Yu Jungeun, Zanotti Stefano, Schilling Lauren, Schoenherr Chris, Economides Aris N, Sanjay Archana, Canalis Ernesto

Abstract excerpt

Mice harboring Notch2 mutations replicating Hajdu-Cheney syndrome (Notch2tm1.1ECan) have osteopenia and exhibit an increase in splenic marginal zone B cells with a decrease in follicular B cells. Whether the altered B-cell allocation is responsible for the osteopenia of Notch2tm1.1ECan mutants is unknown. To determine the effect of NOTCH2 activation in B cells on splenic B-cell allocation and skeletal phenotype,...

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Topics

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Share to Antigens, CD19
Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred C57BL

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Share to Muscle, Skeletal

Share to Receptor, Notch2

Source

Open in PubMed Open full text

Identifiers

PMID: 29545197
DOI: 10.1016/j.ajpath.2018.02.010
PMCID: PMC5971225

Genes

NOTCH1
NOTCH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal Homeostasis.PMID 29545197Read ↗

The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone.Semantic proximity Read ↗

Hairy and enhancer of split 1 is a primary effector of NOTCH2 signaling and induces osteoclast differentiation and function.Semantic proximity Read ↗

Sustained Notch2 signaling in osteoblasts, but not in osteoclasts, is linked to osteopenia in a mouse model of Hajdu-Cheney syndrome.Semantic proximity Read ↗

Osteoblast-specific Notch2 inactivation causes increased trabecular bone mass at specific sites of the appendicular skeleton.Semantic proximity Read ↗

Regulation of B Lymphocyte Development by Histone H2A Deubiquitinase BAP1.Semantic proximity Read ↗

High Bone Turnover in Mice Carrying a Pathogenic Notch2 Mutation Causing Hajdu-Cheney Syndrome.Semantic proximity Read ↗

Induction of a NOTCH3 Lehman syndrome mutation in osteocytes causes osteopenia in male C57BL/6J mice.Semantic proximity Read ↗

Altered Phenotype and Enhanced Antibody-Producing Ability of Peripheral B Cells in Mice with Cd19-Driven Cre Expression.Semantic proximity Read ↗

Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells.Semantic proximity Read ↗

Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation.Semantic proximity Read ↗

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis.Semantic proximity Read ↗

Mice harboring a Hajdu Cheney Syndrome mutation are sensitized to osteoarthritis.Semantic proximity Read ↗

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