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Article

Induction of a NOTCH3 Lehman syndrome mutation in osteocytes causes osteopenia in male C57BL/6J mice.

Bone - 1 Sept 2022

Canalis E, Yee S P, Economides A N, Schilling L, Yu J

Abstract excerpt

Lateral Meningocele or Lehman Syndrome (LMS) is associated with NOTCH3 mutations causing deletions of the PEST domain and a gain-of-NOTCH3 function. We demonstrated that Notch3em1Ecan mice harboring Notch3 mutations analogous to those found in LMS are osteopenic because of enhanced bone resorption. To determine the contribution of specific cell lineages to the phenotype, we created a conditional-by-inversion...

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Share to Abnormalities, Multiple
Share to Bone Diseases, Metabolic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35760307
DOI: 10.1016/j.bone.2022.116476
PMCID: PMC10870228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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