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Article

Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2003

Witt Colleen M, Won Woong-Jai, Hurez Vincent, Klug Christopher A

Abstract excerpt

Recent studies have implicated a role for Notch in the generation of marginal zone (MZ) B cells. To further investigate the role of Notch in the B cell lineage, we have analyzed the effects of reduced Notch2 signaling in mice expressing one functional allele of Notch2 (Notch2(+/-)). Notch2(+/-) mice have reduced B1 B cells of the peritoneal cavity and show a severe reduction in MZ B cells of the spleen. The...

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Identifiers

PMID: 12960298
DOI: 10.4049/jimmunol.171.6.2783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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