Article
The myeloperoxidase-463 G>A polymorphism influences risk of colorectal cancer in southern China: a case-control study.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2011
Li Ying, Qin Yuan, Wang Mei-Lin, Zhu Huan-Feng, Huang Xin-En
Abstract excerpt
OBJECTIVE: Oxidative stress may be involved in colorectal carcinogenesis. Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species (ROS). We hypothesized that the MPO -463 locus polymorphism might therefore contribute to genetic susceptibility to colorectal adenomas. METHODS: RFLP-PCR analysis identified the MPO genotypes in 325 Chinese colorectal adenomas cases and 345...
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