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Article

A zebrafish model of infection-associated acute kidney injury

14 Mar 2018

Abstract excerpt

Sepsis-associated acute kidney injury (S-AKI) independently predicts mortality among critically ill patients. The role of innate immunity in this process is unclear, and there is an unmet need for S-AKI models to delineate the pathophysiological response. Mammals and zebrafish ( Danio rerio) share a conserved nephron structure and homologous innate immune systems, making the latter suitable for S-AKI research. We...

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PMID: 29537312
DOI: 10.1152/ajprenal.00328.2017

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