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Long Non-coding RNA NEAT1, NOD-Like Receptor Family Protein 3 Inflammasome, and Acute Kidney Injury

30 Apr 2024

Abstract excerpt

Key Points Long non-coding RNA (lncRNA) nuclear-enriched abundant transcript 1 ( NEAT1 ) was upregulated in human and murine AKI. It returned to baseline after recovery in humans. Its knockdown preserved kidney function in animals. In vitro , LPS upregulated NEAT1 by TLR4/NF-κB signaling and caused its translocation into the cytoplasm where it activated nucleotide oligomerization domain-like receptor family...

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PMID: 38687867
DOI: 10.1681/asn.0000000000000362

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