Article
Sign of selection on mutation rate modifiers depends on population size.
Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2018
Raynes Yevgeniy, Wylie C Scott, Sniegowski Paul D, Weinreich Daniel M
Abstract excerpt
The influence of population size (N) on natural selection acting on alleles that affect fitness has been understood for almost a century. As N declines, genetic drift overwhelms selection and alleles with direct fitness effects are rendered neutral. Often, however, alleles experience so-called indirect selection, meaning they affect not the fitness of an individual but the fitness distribution of its offspring....
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