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Article

Genetic variants in CYP7A1 and risk of myocardial infarction and symptomatic gallstone disease.

European heart journal - 7 Jun 2018

Qayyum Faiza, Lauridsen Bo K, Frikke-Schmidt Ruth, Kofoed Klaus F, Nordestgaard Børge G, Tybjærg-Hansen Anne

Abstract excerpt

Aims: Myocardial infarction (MI) and gallstone disease (GSD) are intrinsically linked via cholesterol metabolism. We tested the hypothesis that genetic variants in the gene encoding cholesterol 7 alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in the conversion of cholesterol to bile acids in the liver, are associated with risk of MI and GSD in the general population. Methods and results: We performed tests...

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Source

Identifiers

PMID: 29529257
DOI: 10.1093/eurheartj/ehy068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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