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Article

CYP7A1 gene polymorphism located in the 5' upstream region modifies the risk of coronary artery disease.

Disease markers - 1 Jan 2015

Iwanicki Tomasz, Balcerzyk Anna, Niemiec Pawel, Nowak Tomasz, Ochalska-Tyka Anna, Krauze Jolanta, Kosiorz-Gorczynska Sylwia, Grzeszczak Wladyslaw, Zak Iwona

Abstract excerpt

BACKGROUND: 7-Alpha cholesterol hydroxylase (CYP7A1), the first enzyme of classic conversion pathway leading from cholesterol to bile acids synthesis, is encoded by CYP7A1 gene. Its single nucleotide polymorphisms (SNPs) influence serum lipid levels and may be related to impaired lipid profile leading to coronary artery disease (CAD). The aim of the present study was to analyze the possible association between...

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Identifiers

PMID: 25944972
DOI: 10.1155/2015/185969
PMCID: PMC4402502

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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