Article
Enhancement of safety and immunogenicity of the Chinese Hu191 measles virus vaccine by alteration of the S-adenosylmethionine (SAM) binding site in the large polymerase protein.
Virology - 1 May 2018
Wang Yilong, Liu Rongxian, Lu Mijia, Yang Yingzhi, Zhou Duo, Hao Xiaoqiang, Zhou Dongming, Wang Bin, Li Jianrong, Huang Yao-Wei, Zhao Zhengyan
Abstract excerpt
The live-attenuated measles virus (MV) vaccine based on the Hu191 strain has played a significant role in controlling measles in China. However, it has considerable adverse effects that may cause public health burden. We hypothesize that the safety and efficacy of MV vaccine can be improved by altering the S-adenosylmethionine (SAM) binding site in the conserved region VI of the large polymerase protein. To test...
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