Article
Allele-specific expression in a family quartet with autism reveals mono-to-biallelic switch and novel transcriptional processes of autism susceptibility genes.
Scientific reports - 9 Mar 2018
Lin Chun-Yen, Chang Kai-Wei, Lin Chia-Yi, Wu Jia-Ying, Coon Hilary, Huang Pei-Hsin, Ho Hong-Nerng, Akbarian Schahram, Gau Susan Shur-Fen, Huang Hsien-Sung
Abstract excerpt
Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder, and the exact causal mechanism is unknown. Dysregulated allele-specific expression (ASE) has been identified in persons with ASD; however, a comprehensive analysis of ASE has not been conducted in a family quartet with ASD. To fill this gap, we analyzed ASE using genomic DNA from parent and offspring and RNA from offspring's...
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