Article
NOS2 polymorphisms in prediction of benefit from first-line chemotherapy in metastatic colorectal cancer patients.
PloS one - 1 Jan 2018
Schirripa Marta, Zhang Wu, Yang Dongyun, Cao Shu, Okazaki Satoshi, Loupakis Fotios, Berger Martin D, Ning Yan, Miyamoto Yuji, Suenaga Mitsukuni, Alberti Giulia, West Jordan D, Lonardi Sara, Khoukaz Taline, Bergamo Francesca, Battaglin Francesca, Antoniotti Carlotta, Falcone Alfredo, Stintzing Sebastian, Heinemann Volker, Lenz Heinz-Josef
Abstract excerpt
BACKGROUND: Macrophages play a crucial role in the interaction between tumor and immune system, and iNOS is known as a surrogate marker of M1 macrophages activation. The goal of the study was to investigate the role of iNOS polymorphisms as prognostic marker in mCRC patients. MATERIALS AND METHODS: Functional significant polymorphisms in the promoter of INOS gene were analyzed by PCR-based and direct DNA...
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