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Article

Prognostic Impact of IL6 Genetic Variants in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab-Based Chemotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2016

Matsusaka Satoshi, Hanna Diana L, Cao Shu, Zhang Wu, Yang Dongyun, Ning Yan, Sunakawa Yu, Okazaki Satoshi, Berger Martin D, Miyamato Yuji, Parekh Anish, Stintzing Sebastian, Loupakis Fotios, Lenz Heinz-Josef

Abstract excerpt

PURPOSE: The IL6/STAT3 axis promotes inflammation, angiogenesis, and cancer. The effect of genetic variants within this pathway on benefit from antiangiogenic cancer therapy is unknown. We tested whether SNPs in genes involved in IL6/STAT3 signaling can predict efficacy of bevacizumab-based chemotherapy in metastatic colorectal cancer (mCRC) patients. EXPERIMENTAL DESIGN: Associations between potentially...

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Identifiers

PMID: 26839145
DOI: 10.1158/1078-0432.CCR-15-2422
PMCID: PMC4930688

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STAT3

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