eNOS polymorphisms as predictors of efficacy of bevacizumab-based chemotherapy in metastatic colorectal cancer: data from a randomized clinical trial.

doi:10.1186/s12967-015-0619-5

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

eNOS polymorphisms as predictors of efficacy of bevacizumab-based chemotherapy in metastatic colorectal cancer: data from a randomized clinical trial.

Journal of translational medicine - 11 Aug 2015

Ulivi Paola, Scarpi Emanuela, Passardi Alessandro, Marisi Giorgia, Calistri Daniele, Zoli Wainer, Del Re Marzia, Frassineti Giovanni Luca, Tassinari Davide, Tamberi Stefano, Vertogen Bernadette, Amadori Dino

Abstract excerpt

BACKGROUND: Bevacizumab plus chemotherapy is a widely used therapeutic option for first-line treatment of metastatic colorectal cancer (mCRC). However, molecular predictors of bevacizumab efficacy have not yet been identified. We analyzed vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS) polymorphisms in relation to response to bevacizumab. METHODS: Two hundred and...

Topics

Adult
Aged
Aged, 80 and over
Bevacizumab
Colorectal Neoplasms
Disease-Free Survival
Female
Genetic Association Studies
Haplotypes
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Neoplasm Metastasis

Nitric Oxide Synthase Type III

Polymorphism, Single Nucleotide

Treatment Outcome

Vascular Endothelial Growth Factor A

Source

Open in PubMed Open full text

Identifiers

PMID: 26259598
DOI: 10.1186/s12967-015-0619-5
PMCID: PMC4531503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.