Article
Hypersensitivity reactions to therapeutic monoclonal antibodies: Phenotypes and endotypes.
The Journal of allergy and clinical immunology - 1 Jul 2018
Isabwe Ghislaine Annie C, Garcia Neuer Marlene, de Las Vecillas Sanchez Leticia, Lynch Donna-Marie, Marquis Kathleen, Castells Mariana
Abstract excerpt
BACKGROUND: The increasing use of mAbs has led to a rise in hypersensitivity reactions (HSRs), which prevent their use as first-line therapy. HSRs' symptoms, diagnostic tools, and directed management approaches have not been standardized. OBJECTIVE: We propose a novel evidence-based classification of HSRs to mAbs, based on the clinical phenotypes, underlying endotypes and biomarkers, as well as their management...
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