Article
High resolution melting for F9 gene mutation analysis in patients with haemophilia B.
Blood transfusion = Trasfusione del sangue - 1 Jan 2019
Salviato Roberta, Belvini Donata, Radossi Paolo, Tagariello Giuseppe
Abstract excerpt
BACKGROUND: Since 2001, we have used conformation sensitive gel electrophoresis (CSGE) as our first choice for F9 gene mutation screening, leading to the identification of about 300 mutations causing haemophilia B (HB). To circumvent the disadvantages of CSGE, we recently evaluated high-resolution melting analysis (HRM), which represents the next-generation mutation scanning technology. MATERIALS AND METHODS: In...
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