Article

Functional disease architectures reveal unique biological role of transposable elements

2018-11-29

Abstract excerpt

Transposable elements (TE) comprise roughly half of the human genome. Though initially derided as “junk DNA”, they have been widely hypothesized to contribute to the evolution of gene regulation. However, the contribution of TE to the genetic architecture of diseases and complex traits remains unknown. Here, we analyze data from 41 independent diseases and complex traits (average N=320K) to draw three main conclus...

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Literature Corpus work: dd98a001-d3d4-54f5-848e-55f1cdee4636
DOI: 10.1101/482281

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