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Article

Susceptibility of brain atrophy to TRIB3 in Alzheimer's disease, evidence from functional prioritization in imaging genetics.

Proceedings of the National Academy of Sciences of the United States of America - 20 Mar 2018

Lorenzi Marco, Altmann Andre, Gutman Boris, Wray Selina, Arber Charles, Hibar Derrek P, Jahanshad Neda, Schott Jonathan M, Alexander Daniel C, Thompson Paul M, Ourselin Sebastien

Abstract excerpt

The joint modeling of brain imaging information and genetic data is a promising research avenue to highlight the functional role of genes in determining the pathophysiological mechanisms of Alzheimer's disease (AD). However, since genome-wide association (GWA) studies are essentially limited to the exploration of statistical correlations between genetic variants and phenotype, the validation and interpretation of...

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Source

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Identifiers

PMID: 29511103
DOI: 10.1073/pnas.1706100115
PMCID: PMC5866534

Genes

TRIB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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