Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development.

Gene expression patterns : GEP - 1 Dec 2004

Sobrier M-L, Attié-Bitach T, Netchine I, Encha-Razavi F, Vekemans M, Amselem S

Abstract excerpt

The pathophysiology of combined pituitary hormone deficiency (CPHD) is just beginning to be elucidated, with mutations in genes encoding transcription factors expressed at different stages of pituitary development. Among them, the two closely related genes, LHX3 and LHX4, are believed to share redundant biological properties. The patients with a LHX3 mutation display a CPHD phenotype, associated with a rigid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CHO Cells
Share to Cricetulus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypopituitarism

Share to In Situ Hybridization

Share to LIM-Homeodomain Proteins

Share to Pituitary Gland

Share to Pituitary Hormones

Share to Spinal Cord

Source

Identifiers

PMID: 15567726
DOI: 10.1016/j.modgep.2004.07.003

Genes

LHX3
LHX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development.PMID 15567726Read ↗

Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency.Semantic proximity Read ↗

Four novel mutations of the LHX3 gene cause combined pituitary hormone deficiencies with or without limited neck rotation.Semantic proximity Read ↗

Cell-specific actions of a human LHX3 gene enhancer during pituitary and spinal cord development.Semantic proximity Read ↗

Symptomatic heterozygotes and prenatal diagnoses in a nonconsanguineous family with syndromic combined pituitary hormone deficiency resulting from two novel LHX3 mutations.Semantic proximity Read ↗

Mutations in the LHX3 gene cause dysregulation of pituitary and neural target genes that reflect patient phenotypes.Semantic proximity Read ↗

Clinical case seminar: a novel LHX3 mutation presenting as combined pituitary hormonal deficiency.Semantic proximity Read ↗

Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss.Semantic proximity Read ↗

LHX3 and LHX4 transcription factors in pituitary development and disease.Semantic proximity Read ↗

Genomic structure, chromosomal localization, and expression pattern of the human LIM-homeobox3 (LHX 3) gene.Semantic proximity Read ↗

A novel mutation in the LIM homeobox 3 gene is responsible for combined pituitary hormone deficiency, hearing impairment, and vertebral malformations.Semantic proximity Read ↗

LHX3 transcription factor mutations associated with combined pituitary hormone deficiency impair the activation of pituitary target genes.Semantic proximity Read ↗

Roles of the LHX3 and LHX4 LIM-homeodomain factors in pituitary development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.