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Article

How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations.

Oncogene - 1 May 2018

Rehrauer Hubert, Wu Licun, Blum Walter, Pecze Lazslo, Henzi Thomas, Serre-Beinier Véronique, Aquino Catherine, Vrugt Bart, de Perrot Marc, Schwaller Beat, Felley-Bosco Emanuela

Abstract excerpt

Chronic exposure to intraperitoneal asbestos triggered a marked response in the mesothelium well before tumor development. Macrophages, mesothelial precursor cells, cytokines, and growth factors accumulated in the peritoneal lavage. Transcriptome profiling revealed YAP/TAZ activation in inflamed mesothelium with further activation in tumors, paralleled by increased levels of cells with nuclear YAP/TAZ. Arg1 was...

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Identifiers

PMID: 29507420
DOI: 10.1038/s41388-018-0153-z
PMCID: PMC5955862

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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