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Article

Generation of novel neuroinvasive prions following intravenous challenge.

Brain pathology (Zurich, Switzerland) - 1 Nov 2018

Aguilar-Calvo Patricia, Bett Cyrus, Sevillano Alejandro M, Kurt Timothy D, Lawrence Jessica, Soldau Katrin, Hammarström Per, Nilsson K Peter R, Sigurdson Christina J

Abstract excerpt

Prions typically spread into the central nervous system (CNS), likely via peripheral nerves. Yet prion conformers differ in their capacity to penetrate the CNS; certain fibrillar prions replicate persistently in lymphoid tissues with no CNS entry, leading to chronic silent carriers. Subclinical carriers of variant Creutzfeldt-Jakob (vCJD) prions in the United Kingdom have been estimated at 1:2000, and vCJD prions...

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Identifiers

PMID: 29505163
DOI: 10.1111/bpa.12598
PMCID: PMC6123309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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