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Article

Genome-wide stress sensitivity moderates the stress-depression relationship in a nationally representative sample of adults.

Scientific reports - 13 Oct 2021

Davidson Trent, Braudt David B, Keers Robert, Assary Elham, Harris Kathleen Mullan, Boardman Jason D

Abstract excerpt

We re-evaluate the findings of one of the most cited and disputed papers in gene-environment interaction (GxE) literature. In 2003, a paper was published in Science in which the authors demonstrated that the relationship between stress and depression is moderated by a polymorphism in the promoter region (5-HTTLPR) of the gene SLC6A4. Replication has been weak and led many to challenge the overall significance of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34645846
DOI: 10.1038/s41598-021-98684-4
PMCID: PMC8514581

Genes

SLC6A4

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