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Article

Points to Consider Regarding Risk-Reducing Mastectomy in High-, Moderate-, and Low-Penetrance Gene Carriers.

Annals of surgical oncology - 1 Sept 2022

Corso Giovanni, Robson Mark E, Sacchini Virgilio

Abstract excerpt

Risk-reducing mastectomy is considered a safe and effective surgical procedure in high-risk individuals with BRCA1/2 germline mutations. Multigene panels identify women with alterations in breast cancer susceptibility genes other than BRCA1/2. International guidelines classify these genes as high-, moderate-, and low-penetrance based on their associated relative risk for breast cancer. Classification of specific...

Topics

Breast Neoplasms
Female
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease
Humans
Mastectomy
Mutation
Penetrance

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35604619
DOI: 10.1245/s10434-022-11913-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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