Article
Impairment of K-Ras signaling networks and increased efficacy of epidermal growth factor receptor inhibitors by a novel synthetic miR-143.
Cancer science - 1 May 2018
Akao Yukihiro, Kumazaki Minami, Shinohara Haruka, Sugito Nobuhiko, Kuranaga Yuki, Tsujino Takuya, Yoshikawa Yuki, Kitade Yukio
Abstract excerpt
Despite considerable research on K-Ras inhibitors, none had been established until now. We synthesized nuclease-resistant synthetic miR-143 (miR-143#12), which strongly silenced K-Ras, its effector signal molecules AKT and ERK, and the K-Ras activator Sos1. We examined the anti-proliferative effect of miR-143#12 and the mechanism in human colon cancer DLD-1 cell (G13D) and other cell types harboring K-Ras...
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