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Article

Pinprick hypo- and hyperalgesia in diabetic rats: Can diet content affect experimental outcome?

Neuroscience letters - 23 Apr 2018

Yadlapalli Jai Shankar K, Dogra Navdeep, Walbaum Anqi W, Prather Paul L, Crooks Peter A, Dobretsov Maxim

Abstract excerpt

Existing literature concerning the effect of experimentally-induced diabetes on pain thresholds in rodent models remains controversial. In this work, we describe a phenotypical switch from streptozotocin-induced pinprick hypoalgesia to hyperalgesia observed in the same laboratory, in the same strain of rats, obtained from the same vendor, and measured by the same technique carried out by the investigators. This...

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Share to Diabetes Complications
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29490230
DOI: 10.1016/j.neulet.2018.02.054
PMCID: PMC5889730

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