Article
Analysis of the proliferative activity in lung adenocarcinomas with specific driver mutations.
Pathology, research and practice - 1 Mar 2018
Kriegsmann Mark, Harms Alexander, Kazdal Daniel, Fischer Sebastian, Stenzinger Albrecht, Leichsenring Jonas, Penzel Roland, Longuespée Rémi, Kriegsmann Katharina, Muley Thomas, Safi Seyer, Warth Arne
Abstract excerpt
In the last decade it became evident that many lung adenocarcinomas (ADC) harbor key genetic alterations such as KRAS, EGFR or BRAF mutations as well as rearrangements of ROS1 or ALK that drive these tumors. In the present study we investigated whether different driver mutations of ADC result in different proliferation rates, which might have clinical impact, including resistance to therapy, recurrence and...
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