Article
Adverse associations between CX3CR1 polymorphisms and risk of cardiovascular or cerebrovascular disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2005
Lavergne Elise, Labreuche Julien, Daoudi Mehdi, Debré Patrice, Cambien François, Deterre Philippe, Amarenco Pierre, Combadière Christophe
Abstract excerpt
OBJECTIVE: We investigated the role of monocyte-recruiting chemokines in cerebrovascular diseases among the subjects of the GENIC case-control study of brain infarction (BI). METHODS AND RESULTS: Of the genotypes tested, only homozygosity for the rare CX3CR1 alleles was more frequent in cases than in controls: the I249 and M280 alleles were associated with an increased risk of BI (OR, 1.66 and OR, 2.62 with...
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