Article
Somatic Mitochondrial DNA Mutations in Diffuse Large B-Cell Lymphoma.
Scientific reports - 26 Feb 2018
Zeng Andy G X, Leung Andy C Y, Brooks-Wilson Angela R
Abstract excerpt
Diffuse Large B-Cell Lymphoma (DLBCL) is an aggressive hematological cancer for which mitochondrial metabolism may play an important role. Mitochondrial DNA (mtDNA) encodes crucial mitochondrial proteins, yet the relationship between mtDNA and DLBCL remains unclear. We analyzed the functional consequences and mutational spectra of mtDNA somatic mutations and private constitutional variants in 40 DLBCL...
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