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Article

Analysis of age-related changes in psychosine metabolism in the human brain.

PloS one - 1 Jan 2018

Marshall Michael S, Jakubauskas Benas, Bogue Wil, Stoskute Monika, Hauck Zane, Rue Emily, Nichols Matthew, DiAntonio Lisa L, van Breemen Richard B, Kordower Jeffrey H, Saavedra-Matiz Carlos A, Bongarzone Ernesto R

Abstract excerpt

α-Synuclein aggregation has been linked to Gaucher's disease (GD) and Krabbe's disease (KD), lysosomal conditions affecting glycosphingolipid metabolism. α-Synuclein pathology has been directly attributed to the dysregulation of glycosphingolipids in both conditions, specifically to increased galactosylsphingosine (psychosine) content in the context of KD. Furthermore, the gene (GALC) coding for the psychosine...

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Identifiers

PMID: 29481565
DOI: 10.1371/journal.pone.0193438
PMCID: PMC5826537

Genes

GALC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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