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Article

Colorectal cancer spheroid biobanks: multi-level approaches to drug sensitivity studies.

Cell biology and toxicology - 1 Dec 2018

De Angelis Maria Laura, Bruselles Alessandro, Francescangeli Federica, Pucilli Flavia, Vitale Sara, Zeuner Ann, Tartaglia Marco, Baiocchi Marta

Abstract excerpt

Biobanking of molecularly characterized colorectal cancer stem cells (CSCs) generated from individual patients and growing as spheroids in defined serum-free media offer a fast, feasible, and multi-level approach for the screening of targeted therapies and drug resistance molecular studies. By combining in vitro and in vivo analyses of cetuximab efficacy with genetic data on an ongoing collection of stem...

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Identifiers

PMID: 29478126
DOI: 10.1007/s10565-018-9423-3

Genes

EGFR
EGF
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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