Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture.

doi:10.1136/gutjnl-2016-311447

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Circulating tumour cells from patients with colorectal cancer have cancer stem cell hallmarks in ex vivo culture.

Gut - 1 Oct 2017

Grillet Fanny, Bayet Elsa, Villeronce Olivia, Zappia Luke, Lagerqvist Ebba Louise, Lunke Sebastian, Charafe-Jauffret Emmanuelle, Pham Kym, Molck Christina, Rolland Nathalie, Bourgaux Jean François, Prudhomme Michel, Philippe Claire, Bravo Sophie, Boyer Jean Christophe, Canterel-Thouennon Lucile, Taylor Graham Roy, Hsu Arthur, Pascussi Jean Marc, Hollande Frédéric, Pannequin Julie

Abstract excerpt

OBJECTIVE: Although counting of circulating tumour cells (CTC) has attracted a broad interest as potential markers of tumour progression and treatment response, the lack of functional characterisation of these cells had become a bottleneck in taking these observations to the clinic. Our objective was to culture these cells in order to understand them and exploit their therapeutic potential to the full. DESIGN:...

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Identifiers

PMID: 27456153
DOI: 10.1136/gutjnl-2016-311447
PMCID: PMC5595103

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