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Article

Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition.

Cancer research - 1 Mar 2009

Dallas Nikolaos A, Xia Ling, Fan Fan, Gray Michael J, Gaur Puja, van Buren George, Samuel Shaija, Kim Michael P, Lim Sherry J, Ellis Lee M

Abstract excerpt

5-Fluorouracil (5FU) and oxaliplatin are standard therapy for metastatic colorectal cancer (CRC), but the development of chemoresistance is inevitable. Because cancer stem cells (CSC) are hypothesized to be chemoresistant, we investigated CSC properties in newly developed chemoresistant CRC cell lines and sought to identify targets for therapy. The human CRC cell line HT29 was exposed to increasing doses of 5FU...

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Identifiers

PMID: 19244128
DOI: 10.1158/0008-5472.CAN-08-2023
PMCID: PMC3198868

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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