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Article

Somatic mutagenesis in satellite cells associates with human skeletal muscle aging.

Nature communications - 23 Feb 2018

Franco Irene, Johansson Anna, Olsson Karl, Vrtačnik Peter, Lundin Pär, Helgadottir Hafdis T, Larsson Malin, Revêchon Gwladys, Bosia Carla, Pagnani Andrea, Provero Paolo, Gustafsson Thomas, Fischer Helene, Eriksson Maria

Abstract excerpt

Human aging is associated with a decline in skeletal muscle (SkM) function and a reduction in the number and activity of satellite cells (SCs), the resident stem cells. To study the connection between SC aging and muscle impairment, we analyze the whole genome of single SC clones of the leg muscle vastus lateralis from healthy individuals of different ages (21-78 years). We find an accumulation rate of 13 somatic...

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Identifiers

PMID: 29476074
DOI: 10.1038/s41467-018-03244-6
PMCID: PMC5824957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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