Article
Genomic Alterations and Complex Subclonal Architecture in Sporadic GH-Secreting Pituitary Adenomas.
The Journal of clinical endocrinology and metabolism - 1 May 2018
Hage Mirella, Viengchareun Say, Brunet Erika, Villa Chiara, Pineau Dominique, Bouligand Jérôme, Teglas Jean-Paul, Adam Clovis, Parker Fabrice, Lombès Marc, Tachdjian Gérard, Gaillard Stéphane, Chanson Philippe, Tosca Lucie, Kamenický Peter
Abstract excerpt
Purpose: The molecular pathogenesis of growth hormone-secreting pituitary adenomas is not fully understood. Cytogenetic alterations might serve as alternative driver events in GNAS mutation-negative somatotroph tumors. Experimental Design: We performed cytogenetic profiling of pituitary adenomas obtained from 39 patients with acromegaly and four patients with sporadic gigantism by using array comparative genomic...
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