Article
Landscape of Genomic Alterations in Pituitary Adenomas.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2017
Bi Wenya Linda, Horowitz Peleg, Greenwald Noah F, Abedalthagafi Malak, Agarwalla Pankaj K, Gibson Wiliam J, Mei Yu, Schumacher Steven E, Ben-David Uri, Chevalier Aaron, Carter Scott, Tiao Grace, Brastianos Priscilla K, Ligon Azra H, Ducar Matthew, MacConaill Laura, Laws Edward R, Santagata Sandro, Beroukhim Rameen, Dunn Ian F
Abstract excerpt
Purpose: Pituitary adenomas are the second most common primary brain tumor, yet their genetic profiles are incompletely understood.Experimental Design: We performed whole-exome sequencing of 42 pituitary macroadenomas and matched normal DNA. These adenomas included hormonally active and inactive tumors, ones with typical or atypical histology, and ones that were primary or recurrent.Results: We identified...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.