Article
Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack.
Blood advances - 27 Feb 2018
Espinoza J Luis, Elbadry Mahmoud I, Chonabayashi Kazuhisa, Yoshida Yoshinori, Katagiri Takamasa, Harada Kenichi, Nakagawa Noriharu, Zaimoku Yoshitaka, Imi Tatsuya, Takamatsu Hiroyuki, Ozawa Tatsuhiko, Maruyama Hiroyuki, Hassanein Hassan A, Khalifa A Noreldin Amal, Takenaka Katsuto, Akashi Koichi, Hamana Hiroshi, Kishi Hiroyuki, Akatsuka Yoshiki, Nakao Shinji
Abstract excerpt
Hematopoietic stem cells (HSCs) that lack HLA-class I alleles as a result of copy-number neutral loss of heterozygosity of the short arm of chromosome 6 (6pLOH) or HLA allelic mutations often constitute hematopoiesis in patients with acquired aplastic anemia (AA), but the precise mechanisms underlying clonal hematopoiesis induced by these HLA-lacking (HLA-) HSCs remain unknown. To address this issue, we generated...
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