Article
Targeted Next-Generation Sequencing Is a Sensitive Tool for Differential Diagnosis of Myelodysplastic Syndromes in Bone Marrow Trephines.
The Journal of molecular diagnostics : JMD - 1 May 2018
Bräuninger Andreas, Blau Wolfgang, Kunze Kristin, Desch Ann-Kathrin, Brobeil Alexander, Tur Mehmet K, Etschmann Benjamin, Günther Ulrich, Körholz Dieter, Schliesser Georg, Käbisch Andreas, Kiehl Michael, Rummel Mathias, Gattenlöhner Stefan
Abstract excerpt
Myelodysplastic syndromes are hematological neoplasias in which immunohistologic examination of bone marrow trephines is important for a definite diagnosis. Unequivocal distinction from reactive bone marrow changes is, however, sometimes difficult. Because neoplastic clones in myelodysplastic syndrome carry mutations in recurrent genes, mutation detection by targeted next-generation sequencing may be a useful...
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