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Article

Altered expression of the Cdk5 activator-like protein, Cdk5α, causes neurodegeneration, in part by accelerating the rate of aging.

Disease models & mechanisms - 8 Mar 2018

Spurrier Joshua, Shukla Arvind Kumar, McLinden Kristina, Johnson Kory, Giniger Edward

Abstract excerpt

Aging is the greatest risk factor for neurodegeneration, but the connection between the two processes remains opaque. This is in part for want of a rigorous way to define physiological age, as opposed to chronological age. Here, we develop a comprehensive metric for physiological age in Drosophila, based on genome-wide expression profiling. We applied this metric to a model of adult-onset neurodegeneration,...

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PMID: 29469033
DOI: 10.1242/dmm.031161
PMCID: PMC5897722

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